Lab of Reactive Myeloid Cell Biology Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Center (MECCC)

Below are a list of selected publications from the Hegde group. For more complete list, please refer to MyNCBI/Pubmed.

Highlighted

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Samarth Hegde, Bruno Giotti, Brian Y. Soong, Laszlo Halasz, Jessica Le Berichel, …, Alexander M. Tsankov, Thomas U. Marron, Sai Ma, Brian D. Brown, Miriam Merad
Nature  ·  10 Sep 2025  ·  doi:10.1038/s41586-025-09493-y
epigenetics lung-cancer bone-marrow

All

2025

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Samarth Hegde, Bruno Giotti, Brian Y. Soong, Laszlo Halasz, Jessica Le Berichel, …, Alexander M. Tsankov, Thomas U. Marron, Sai Ma, Brian D. Brown, Miriam Merad
Nature  ·  10 Sep 2025  ·  doi:10.1038/s41586-025-09493-y
epigenetics lung-cancer bone-marrow
Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma PDAC exhibit divergent immune cell selection and immunosuppressive mechanisms
Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms
Shivan Sivakumar, Ashwin Jainarayanan, Edward Arbe-Barnes, Piyush Kumar Sharma, Maire Ni Leathlobhair, …, Benjamin Fairfax, Miriam Merad, Michael L. Dustin, Enas Abu-Shah, Rachael Bashford-Rogers
Nature Communications  ·  06 Feb 2025  ·  doi:10.1038/s41467-024-55424-2
transcriptomics pancreatic-cancer collaboration

2024

Hematopoietic aging promotes cancer by fueling IL-1 driven emergency myelopoiesis
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Matthew D. Park, Jessica Le Berichel, Pauline Hamon, C. Matthias Wilk, Meriem Belabed, …, Julian Downward, Nicolas Vabret, Brian D. Brown, Thomas U. Marron, Miriam Merad
Science  ·  25 Oct 2024  ·  doi:10.1126/science.adn0327
lung-cancer aging bone-marrow transcriptomics
Informing biologically relevant signal from spatial transcriptomic data
Informing biologically relevant signal from spatial transcriptomic data
Emir Radkevich, Darwin D’Souza, Raphael Mattiuz, Raphael Merand, Rachel Chen, …, Zhihong Chen, Seunghee Kim-Schulze, Sacha Gnjatic, Miriam Merad, Vladimir Roudko
openRxiv  ·  13 Sep 2024  ·  doi:10.1101/2024.09.09.610361
Editorial: Towards a more faithful ex vivo modelling of tumor-immune-stroma communication
Editorial: Towards a more faithful ex vivo modelling of tumor-immune-stroma communication
Samarth Hegde
Frontiers in Cell and Developmental Biology  ·  13 Aug 2024  ·  doi:10.3389/fcell.2024.1462915
Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Bruno Giotti, Komal Dolasia, William Zhao, Peiwen Cai, Robert Sweeney, …, Amir Horowitz, Thomas U. Marron, Anna Tocheva, Andrea Wolf, Alexander M. Tsankov
Cancer Discovery  ·  03 Jul 2024  ·  doi:10.1158/2159-8290.CD-23-0017
lung-cancer transcriptomics collaboration
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
Samarth Hegde, Bruno Giotti, Brian Y. Soong, Laszlo Halasz, Jessica Le Berichel, …, Sai Ma, Alexander M. Tsankov, Thomas U. Marron, Brian D. Brown, Miriam Merad
openRxiv  ·  28 Jun 2024  ·  doi:10.1101/2024.06.24.600383
Single cell view of tumor microenvironment gradients in pleural mesothelioma
Single cell view of tumor microenvironment gradients in pleural mesothelioma
Bruno Giotti, Komal Dolasia, William Zhao, Peiwen Cai, Robert Sweeney, …, Amir Horowitz, Thomas U Marron, Anna Tocheva, Andrea Wolf, Alexander M. Tsankov
openRxiv  ·  15 Mar 2024  ·  doi:10.1101/2024.03.14.585048

2023

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis
Nelson M. LaMarche, Samarth Hegde, Matthew D. Park, Barbara B. Maier, Leanna Troncoso, …, Brian D. Brown, Fred R. Hirsch, Brian S. Kim, Thomas U. Marron, Miriam Merad
Nature  ·  06 Dec 2023  ·  doi:10.1038/s41586-023-06797-9
lung-cancer bone-marrow transcriptomics
Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments
Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments
Shivan Sivakumar, Ashwin Jainarayanan, Edward Arbe-Barnes, Piyush Kumar Sharma, Maire Ni Leathlobhair, …, Benjamin Fairfax, Miriam Merad, Michael L. Dustin, Enas Abu-Shah, Rachael Bashford-Rogers
openRxiv  ·  01 Sep 2023  ·  doi:10.1101/2023.08.31.555730
Intratumoral dendritic cell CD4 T helper cell niches enable CD8 T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Assaf Magen, Pauline Hamon, Nathalie Fiaschi, Brian Y. Soong, Matthew D. Park, …, Myron Schwartz, Thomas U. Marron, Gavin Thurston, Alice O. Kamphorst, Miriam Merad
Nature Medicine  ·  01 Jun 2023  ·  doi:10.1038/s41591-023-02345-0
liver-cancer spatial tissue-biology transcriptomics
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
Matthew D. Park, Ivan Reyes-Torres, Jessica LeBerichel, Pauline Hamon, Nelson M. LaMarche, …, Brian D. Brown, Lucas Ferrari De Andrade, Marco Colonna, Thomas U. Marron, Miriam Merad
Nature Immunology  ·  20 Apr 2023  ·  doi:10.1038/s41590-023-01475-4
lung-cancer transcriptomics tissue-biology
On the Biology and Therapeutic Modulation of Macrophages and Dendritic Cells in Cancer
On the Biology and Therapeutic Modulation of Macrophages and Dendritic Cells in Cancer
Matthew D. Park, Meriem Belabed, Steven T. Chen, Pauline Hamon, Samarth Hegde, Raphaël Mattiuz, Thomas U. Marron, Miriam Merad
Annual Review of Cancer Biology  ·  11 Apr 2023  ·  doi:10.1146/annurev-cancerbio-061521-085949

2022

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
Assaf Magen, Pauline Hamon, Nathalie Fiaschi, Leanna Troncoso, Etienne Humblin, …, Myron Schwartz, Thomas U. Marron, Gavin Thurston, Alice O. Kamphorst, Miriam Merad
openRxiv  ·  26 Jun 2022  ·  doi:10.1101/2022.06.22.497216

2021

MDSC: Markers, development, states, and unaddressed complexity
MDSC: Markers, development, states, and unaddressed complexity
Samarth Hegde, Andrew M. Leader, Miriam Merad
Immunity  ·  01 May 2021  ·  doi:10.1016/j.immuni.2021.04.004

2020

Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine
Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine
Samarth Hegde
Indian Journal of Surgical Oncology  ·  25 Aug 2020  ·  doi:10.1007/s13193-020-01192-6
Many paths to COVID-19 lymphocyte dysfunction
Many paths to COVID-19 lymphocyte dysfunction
Samarth Hegde
Nature Reviews Immunology  ·  05 Jun 2020  ·  doi:10.1038/s41577-020-0361-y
Immunology of COVID-19: Current State of the Science
Immunology of COVID-19: Current State of the Science
Nicolas Vabret, Graham J. Britton, Conor Gruber, Samarth Hegde, Joel Kim, …, Emilie Grasset, Peter Heeger, Ephraim Kenigsberg, Florian Krammer, Uri Laserson
Immunity  ·  01 Jun 2020  ·  doi:10.1016/j.immuni.2020.05.002
Does asthma make COVID-19 worse
Does asthma make COVID-19 worse?
Samarth Hegde
Nature Reviews Immunology  ·  28 Apr 2020  ·  doi:10.1038/s41577-020-0324-3
Advancing scientific knowledge in times of pandemics
Advancing scientific knowledge in times of pandemics
Nicolas Vabret, Robert Samstein, Nicolas Fernandez, Miriam Merad
Nature Reviews Immunology  ·  23 Apr 2020  ·  doi:10.1038/s41577-020-0319-0
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
Samarth Hegde, Varintra E. Krisnawan, Brett H. Herzog, Chong Zuo, Marcus A. Breden, …, William G. Hawkins, Ryan C. Fields, Carl J. DeSelm, Julie K. Schwarz, David G. DeNardo
Cancer Cell  ·  01 Mar 2020  ·  doi:10.1016/j.ccell.2020.02.008
pancreatic-cancer therapy tissue-biology

2019

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies
Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies
Roheena Z. Panni, John M. Herndon, Chong Zuo, Samarth Hegde, Graham D. Hogg, …, Buck E. Rogers, Ryan C. Fields, William G. Hawkins, Vineet Gupta, David G. DeNardo
Science Translational Medicine  ·  03 Jul 2019  ·  doi:10.1126/scitranslmed.aau9240
pancreatic-cancer therapy tissue-biology
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
Hong Jiang, Xiuting Liu, Brett L Knolhoff, Samarth Hegde, Kyung Bae Lee, Hongmei Jiang, Ryan C Fields, Jonathan A Pachter, Kian-Huat Lim, David G DeNardo
Gut  ·  10 May 2019  ·  doi:10.1136/gutjnl-2018-317424
pancreatic-cancer therapy fibrosis tissue-biology

2017

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
Hong Jiang, Samarth Hegde, David G. DeNardo
Cancer Immunology, Immunotherapy  ·  27 Apr 2017  ·  doi:10.1007/s00262-017-2003-1
pancreatic-cancer tissue-biology fibrosis

2016

Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin
Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin
Ambika S. Kurbet, Samarth Hegde, Oindrila Bhattacharjee, Srujan Marepally, Praveen K. Vemula, Srikala Raghavan
Cell Reports  ·  01 Sep 2016  ·  doi:10.1016/j.celrep.2016.08.062
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Hong Jiang, Samarth Hegde, Brett L Knolhoff, Yu Zhu, John M Herndon, …, Irina M Shapiro, David T Weaver, Jonathan A Pachter, Andrea Wang-Gillam, David G DeNardo
Nature Medicine  ·  04 Jul 2016  ·  doi:10.1038/nm.4123
pancreatic-cancer tissue-biology fibrosis

2013

A Skin-depth Analysis of Integrins: Role of the Integrin Network in Health and Disease
A Skin-depth Analysis of Integrins: Role of the Integrin Network in Health and Disease
Samarth Hegde, Srikala Raghavan
Cell Communication & Adhesion  ·  08 Nov 2013  ·  doi:10.3109/15419061.2013.854334
Low-barrier hydrogen bonds in proteins
Low-barrier hydrogen bonds in proteins
M. V. Hosur, R. Chitra, Samarth Hegde, R. R. Choudhury, Amit Das, R. V. Hosur
Crystallography Reviews  ·  01 Jan 2013  ·  doi:10.1080/0889311X.2013.771633